Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 8/31 | H | AR-Pine Bluff (6-5) | [FCS:SWAC] | W | 39-7 | |
| 9/14 | A | Purdue (4-8) | [P4:Big Ten] | W | 34-13 | |
| 9/21 | H | SMU (10-2) | [G5:AAC] | L | 38-41 | |
| 9/28 | H | Kansas (3-9) | [P4:Big 12] | W | 51-14 | |
| 10/5 | A | Iowa State (7-5) | [P4:Big 12] | L | 24-49 | |
| 10/19 | A | Kansas St (8-4) | [P4:Big 12] | L | 17-24 | |
| 10/26 | H | Texas (7-5) | [P4:Big 12] | W | 37-27 | |
| 11/2 | A | Oklahoma St (8-4) | [P4:Big 12] | L | 27-34 | |
| 11/9 | H | Baylor (11-2) | [P4:Big 12] | L | 23-29 | |
| 11/16 | A | Texas Tech (4-8) | [P4:Big 12] | W | 33-31 | |
| 11/23 | A | Oklahoma (12-1) | [P4:Big 12] | L | 24-28 | |
| 11/29 | H | West Virginia (5-7) | [P4:Big 12] | L | 17-20 |