ACC rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/12 | A | Notre Dame (10-1) | [P4:ACC] | L | 13-27 | |
| 9/19 | H | Boston College (6-5) | [P4:ACC] | L | 6-26 | |
| 9/26 | A | Virginia (5-5) | [P4:ACC] | L | 20-38 | |
| 10/3 | H | Virginia Tech (5-6) | [P4:ACC] | L | 31-38 | |
| 10/10 | A | Syracuse (1-10) | [P4:ACC] | W | 38-24 | |
| 10/17 | A | NC State (8-3) | [P4:ACC] | L | 20-31 | |
| 10/31 | H | Charlotte (2-4) | [G5:CUSA] | W | 53-19 | |
| 11/7 | H | North Carolina (8-3) | [P4:ACC] | L | 24-56 | |
| 11/21 | H | Wake Forest (4-4) | [P4:ACC] | canceled | ||
| 11/28 | A | Georgia Tech (3-7) | [P4:ACC] | L | 33-56 | |
| 12/5 | H | Miami (8-2) | [P4:ACC] | L | 0-48 | |
| 12/12 | A | Florida St (3-6) | [P4:ACC] | L | 35-56 |