Big Ten rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/5 | H | Richmond (8-3) | [FCS:CAA] | W | 50-21 | |
| 9/12 | H | Bowling Green (10-3) | [G5:MAC] | L | 27-48 | |
| 9/19 | H | South Florida (8-4) | [G5:AAC] | W | 35-17 | |
| 9/26 | A | West Virginia (7-5) | [P4:Big 12] | L | 6-45 | |
| 10/3 | H | Michigan (9-3) | [P4:Big Ten] | L | 0-28 | |
| 10/10 | A | Ohio State (11-1) | [P4:Big Ten] | L | 28-49 | |
| 10/24 | N | Penn State (7-5) | [P4:Big Ten] | L | 30-31 | |
| 10/31 | A | Iowa (12-1) | [P4:Big Ten] | L | 15-31 | |
| 11/7 | H | Wisconsin (9-3) | [P4:Big Ten] | L | 24-31 | |
| 11/14 | A | Michigan St (12-1) | [P4:Big Ten] | L | 7-24 | |
| 11/21 | H | Indiana (6-6) | [P4:Big Ten] | L | 28-47 | |
| 11/28 | A | Rutgers (4-8) | [P4:Big Ten] | W | 46-41 |