ACC rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/1 | H | UCF (10-3) | [G5:CUSA] | L | 23-25 | |
| 9/8 | A | Boston College (10-3) | [P4:ACC] | L | 17-37 | |
| 9/15 | H | Wofford (8-3) | [FCS:SOUTH] | W | 38-17 | |
| 9/22 | H | Clemson (9-3) | [P4:ACC] | L | 20-42 | |
| 9/29 | H | Louisville (6-6) | [P4:Big East] | L | 10-29 | |
| 10/6 | A | Florida St (7-5) | [P4:ACC] | L | 10-27 | |
| 10/20 | A | East Carolina (7-5) | [G5:CUSA] | W | 34-20 | |
| 10/27 | H | Virginia (9-3) | [P4:ACC] | W | 29-24 | |
| 11/3 | A | Miami (5-7) | [P4:ACC] | W | 19-16 | |
| 11/10 | H | North Carolina (4-8) | [P4:ACC] | W | 31-27 | |
| 11/17 | A | Wake Forest (8-4) | [P4:ACC] | L | 18-38 | |
| 11/24 | H | Maryland (6-6) | [P4:ACC] | L | 0-37 |