Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 8/31 | H | Louisiana (3-9) | [G5:Sun Belt] | W | 31-7 | |
| 9/7 | A | Pitt (8-4) | [P4:Big East] | W | 14-12 | |
| 9/21 | H | Virginia Tech (9-4) | [P4:Big East] | L | 3-13 | |
| 9/28 | H | Louisiana Tech (4-8) | [G5:WAC] | W | 31-3 | |
| 10/5 | H | Texas Tech (8-5) | [P4:Big 12] | L | 47-48 | |
| 10/12 | A | Baylor (3-9) | [P4:Big 12] | W | 41-0 | |
| 10/19 | A | Kansas (2-10) | [P4:Big 12] | W | 47-22 | |
| 10/26 | H | Nebraska (7-6) | [P4:Big 12] | L | 31-38 | |
| 11/2 | A | Oklahoma St (7-5) | [P4:Big 12] | L | 23-28 | |
| 11/9 | H | Oklahoma (11-2) | [P4:Big 12] | W | 30-26 | |
| 11/16 | H | Missouri (5-7) | [P4:Big 12] | L | 27-33 | |
| 11/29 | A | Texas (10-2) | [P4:Big 12] | L | 20-50 |