Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/2 | H | Sam Houston (3-9) | [G5:CUSA] | W | 14-0 | |
| 9/9 | H | Southern Utah (6-5) | [FCS:UAC] | W | 41-16 | |
| 9/16 | A | Arkansas (4-8) | [P4:SEC] | W | 38-31 | |
| 9/23 | A | Kansas (8-4) | [P4:Big 12] | L | 27-38 | |
| 9/29 | H | Cincinnati (3-9) | [P4:Big 12] | W | 35-27 | |
| 10/14 | A | TCU (5-7) | [P4:Big 12] | L | 11-44 | |
| 10/21 | H | Texas Tech (6-6) | [P4:Big 12] | W | 27-14 | |
| 10/28 | A | Texas (12-1) | [P4:Big 12] | L | 6-35 | |
| 11/4 | A | West Virginia (8-4) | [P4:Big 12] | L | 7-37 | |
| 11/11 | H | Iowa State (7-5) | [P4:Big 12] | L | 13-45 | |
| 11/18 | H | Oklahoma (10-2) | [P4:Big 12] | L | 24-31 | |
| 11/25 | A | Oklahoma St (9-4) | [P4:Big 12] | L | 34-40 |