MAC rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/1 | A | Nebraska (4-8) | [P4:Big Ten] | canceled | ||
| 9/8 | H | Morgan St (4-7) | [FCS:MEAC] | W | 41-7 | |
| 9/15 | A | Northwestern (8-5) | [P4:Big Ten] | W | 39-34 | |
| 9/22 | A | Iowa State (8-4) | [P4:Big 12] | L | 13-26 | |
| 10/6 | H | Miami OH (6-6) | [G5:MAC] | L | 17-41 | |
| 10/13 | A | Buffalo (10-3) | [G5:MAC] | L | 6-24 | |
| 10/20 | A | Kent State (2-10) | [G5:MAC] | W | 24-23 | |
| 10/27 | H | C Michigan (1-11) | [G5:MAC] | W | 17-10 | |
| 11/1 | H | N Illinois (8-5) | [G5:MAC] | L | 26-36 | |
| 11/10 | A | E Michigan (7-5) | [G5:MAC] | L | 7-27 | |
| 11/17 | H | Bowling Green (3-9) | [G5:MAC] | L | 6-21 | |
| 11/23 | A | Ohio (8-4) | [G5:MAC] | L | 28-49 | |
| 12/1 | A | South Carolina (7-5) | [P4:SEC] | L | 3-28 |