Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/1 | H | Bowling Green (8-3) | [G5:MAC] | L | 13-20 | |
| 9/8 | H | Texas St (4-7) | [FCS:LAND] | W | 40-6 | |
| 9/15 | A | Michigan St (6-5) | [P4:Big Ten] | canceled | ||
| 9/29 | H | Nebraska (10-1) | [P4:Big 12] | L | 3-36 | |
| 10/6 | A | Oklahoma St (4-7) | [P4:Big 12] | W | 41-38 | |
| 10/13 | H | Iowa State (7-4) | [P4:Big 12] | L | 14-20 | |
| 10/20 | A | Kansas (3-8) | [P4:Big 12] | W | 38-34 | |
| 10/27 | H | Texas (10-2) | [P4:Big 12] | L | 16-35 | |
| 11/3 | A | Colorado (10-2) | [P4:Big 12] | L | 24-38 | |
| 11/10 | H | Baylor (3-8) | [P4:Big 12] | W | 41-24 | |
| 11/24 | A | Kansas St (6-5) | [P4:Big 12] | L | 3-24 | |
| 12/1 | A | Michigan St (6-5) | [P4:Big Ten] | L | 7-55 |