Big Ten rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 8/28 | H | Miami OH (7-6) | [G5:MAC] | W | 17-0 | |
| 9/6 | H | MTSU (3-9) | [G5:CUSA] | W | 42-10 | |
| 9/13 | A | Alabama (10-3) | [P4:SEC] | L | 14-38 | |
| 9/20 | H | Maryland (4-8) | [P4:Big Ten] | L | 10-27 | |
| 10/4 | A | Michigan (9-3) | [P4:Big Ten] | L | 10-24 | |
| 10/11 | H | Iowa (8-4) | [P4:Big Ten] | L | 0-37 | |
| 10/18 | H | Ohio State (12-1) | [P4:Big Ten] | L | 0-34 | |
| 10/25 | A | Oregon (11-1) | [P4:Big Ten] | L | 7-21 | |
| 11/8 | H | Washington (8-4) | [P4:Big Ten] | W | 13-10 | |
| 11/15 | A | Indiana (13-0) | [P4:Big Ten] | L | 7-31 | |
| 11/22 | H | Illinois (8-4) | [P4:Big Ten] | W | 27-10 | |
| 11/29 | A | Minnesota (7-5) | [P4:Big Ten] | L | 7-17 |